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Bleeding before prophylaxis in severe hemophilia: paradigm shift over two decades

Van Creveldkliniek, Center for Benign Hematology, Thrombosis and Hemostasis, University Medical Center Utrecht, Netherlands
Unitat Hemofilia Hospital Vall d’Hebron, Barcelona, Spain
Division of Haematology/Oncology, Department of Paediatrics and Child Health Evaluative Sciences, Research Institute, The Hospital for Sick Children, Toronto, ON, Canada
Unidad de Hemostasia y Trombosis, Hospital Universitario la Fe, Valencia, Spain
CHU Purpan Centre de traitement des hémophiles, Toulouse, France
Dr. von Haunersches Children’s Hospital, University of Munich, Germany
Lund University, Department of Clinical Sciences Lund -Paediatrics and Malmö Haemostasis & Thrombosis Centre, Skåne University Hospital, Malmö, Sweden
Department of Haematology Oncology, Our Lady’s Children’s Hospital, Crumlin, Dublin, Ireland
Paediatric Department of Coagulation Disorders, Karolinska University Hospital, Stockholm, Sweden
St. Sophia Children’s Hospital, Haemophilia-Haemostasis Unit, Athens, Greece
Centre Régional de Traitement de l’Hémophilie et Autres Maladies Hémorragiques, Centre Hospitalier Universitaire de Bicêtre, Paris, France
Department of Haematology, Royal Hospital for Sick Children, Edinburgh, Scotland
Van Creveldkliniek, Center for Benign Hematology, Thrombosis and Hemostasis, University Medical Center Utrecht, Netherlands;Julius Center for Health Sciences and Primary Care, University Medical Center, Utrecht, The Netherlands
Vol. 100 No. 3 (2015): March, 2015 https://doi.org/10.3324/haematol.2014.115709